North American Menopause Society (NAMS) has updated its 2010 position statement on the use of estrogen therapy (ET) and estrogen-progestogen therapy (EPT) (published online February 27, 2011 in Menopause: The Journal of The North American Menopause Society).
2.Heightened risk for breast cancer associated with more than 3 to 5 years of Estrogen+Progesterone Therapy (EPT) use limits the duration of safe EPT use. For Estrogen Therapy(ET), the benefit–risk profile is more favorable. Because risk for breast cancer does not appear to increase during an average of 7 years of ET use, there is more flexibility in duration of ET treatment.
3.HRT use is associated with a lower fracture risk, but a higher risk for ischemic stroke, venous thromboembolism (VTE), and ovarian cancer.
4.Compared with ET, EPT is associated with a higher risk for coronary artery disease.
5.Women with premature or early menopause and no contraindications to HRT may use HRT until age 51 years, which is the average age of natural menopause, or longer if needed to control symptoms.
Highlights of the specific recommendations include:
1.The most effective treatment for menopausal vasomotor symptoms and associated quality of life is Estrogen Therapy or Estrogen+Progesterone Therapy.2.Heightened risk for breast cancer associated with more than 3 to 5 years of Estrogen+Progesterone Therapy (EPT) use limits the duration of safe EPT use. For Estrogen Therapy(ET), the benefit–risk profile is more favorable. Because risk for breast cancer does not appear to increase during an average of 7 years of ET use, there is more flexibility in duration of ET treatment.
3.HRT use is associated with a lower fracture risk, but a higher risk for ischemic stroke, venous thromboembolism (VTE), and ovarian cancer.
4.Compared with ET, EPT is associated with a higher risk for coronary artery disease.
5.Women with premature or early menopause and no contraindications to HRT may use HRT until age 51 years, which is the average age of natural menopause, or longer if needed to control symptoms.
Take Home Message:
Hormone Replacement Therapy can be used judiciously for menopausal vasomotor symptoms.It should not be solely used for prevention of osteoporosis or cardiovascular disease. In fact, it may increase cardiovascular disease.
No comments:
Post a Comment